American Dad! centers on the Smith family and the various obstacles Stan, a CIA employee, encounters with his immediate family and in his efforts to ensure the safety of his country. The Smith family lives in the fictional U.S. community of "Langley Falls, Virginia" in the Washington, D.C. metropolitan area. The town name is a composite of Langley, Virginia and Great Falls, Virginia, both of which are located in Fairfax County. Langley is the real-life location of CIA headquarters.
- Seth MacFarlane as Stan Smith / Roger Smith
- Wendy Schaal as Francine Smith
- Scott Grimes as Steve Smith
- Rachael MacFarlane as Hayley Smith
- Dee Bradley Baker as Klaus Heissler
- Patrick Stewart as Deputy Director Avery Bullock