The show centers on a family that runs a hamburger restaurant. Loren Bouchard stated Bob's Burgers came out because of Fox's animation brand centers mostly on family, but that he also wanted to dabble in workplace comedy. The show is said to fill the void created by the cancellation of King of the Hill, which Bob's Burgers executive producer Jim Dauterive worked on for nearly its entire run.
- H. Jon Benjamin - Bob Belcher
- John Roberts - Linda Belcher
- Dan Mintz - Tina Belcher
- Eugene Mirman - Gene Belcher
- Kristen Schaal - Louise Belcher
- Larry Murphy - Teddy