Family Guy usually revolves around the adventures of Peter Griffin, a bumbling but well-intentioned blue-collar worker. His wife Lois is generally a stay-at-home mother and piano teacher. Peter and Lois have three children: teenage daughter Meg, who is frequently the butt of Peter's jokes due to her homeliness and lack of popularity; teenage son Chris, who is overweight, unintelligent and, in many respects, a younger version of his father; and son Stewie, a diabolical infant of ambiguous sexual orientation who has adult mannerisms and speaks fluently with what some consider an upper-class affected English accent and stereotypical archvillain phrases. Living with the family is Brian, the family dog, who is highly anthropomorphized, walks on two legs, drinks Martinis, smokes cigarettes and engages in human conversation, though he is still considered a pet in many respects.
- Seth MacFarlane - Peter Griffin / Stewie Griffin / Brian Griffin / Glenn Quagmire
- Alex Borstein - Lois Griffin
- Mila Kunis - Meg Griffin
- Seth Green - Chris Griffin
- Patrick Warburton - Joe Swanson
- Mike Henry - Cleveland