The lives of two geniuses named Dr. Leonard Hofstader and Dr. Sheldon Cooper change when they meet their new neighbor; motivated but unsuccessful actress Penny, who now works as a waitress at The Cheesecake Factory. As they struggle socially, Penny decides to help them discover the world that they know everything about, but yet know nothing about how to live in it. Friends Howard and Rajesh are along for the ride.
- Johnny Galecki
- Jim Parsons
- Kaley Cuoco
- Simon Helberg
- Kunal Nayyar
- Sara Gilbert
- Mayim Bialik
- Melissa Rauch
- Kevin Sussman
- Laura Spencer
- In August 2009, the sitcom won the best comedy series TCA award and Jim Parsons (Sheldon) won the award for individual achievement in comedy.
- In 2010, the show won the People's Choice Award for Favorite Comedy, while Parsons won a Primetime Emmy Award for Outstanding Lead Actor in a Comedy Series.
- On January 16, 2011, Parsons was awarded a Golden Globe for Best Performance by an Actor in a Television Series – Comedy or Musical, an award that was presented by co-star Kaley Cuoco.
- On September 18, 2011, Parsons was again awarded an Emmy for Best Actor in a Comedy Series.
- On January 9, 2013, the show won People's Choice Award for Favorite Comedy for a second time.
- On August 25, 2014, Jim Parsons was awarded an Emmy for Best Actor in a Comedy Series.
- The Big Bang Theory also won the 2016 People's Choice Awards for under Favorite TV Show and Favorite Network TV Comedy with Jim Parsons winning Favorite Comedic TV Actor.
- On January 20, 2016, The Big Bang Theory also won the International category at the UK's National Television Awards.