Uncle Grandpa, the magical uncle and grandpa who is the uncle-grandpa and brother-dad of every child and adult in the world, stops by children's houses every day to see how they are doing. The children he visits have a problem of their own and Uncle Grandpa tries to help them through a series of chaotic and surreal misadventures. He is a clowny sort of person who sometimes eats inedible objects (paper, and mostly books). He drives/lives in a recreational vehicle (RV) and is accompanied by a red talking fanny pack named Belly Bag, an anthropomorphic dinosaur named Mr. Gus, a photo cutout of a tiger named Giant Realistic Flying Tiger, and a talking pizza slice named Pizza Steve.
- Peter Browngardt as Uncle Grandpa
- Adam DeVine as Pizza Steve
- Kevin Michael Richardson as Mr. Gus
- Eric Bauza as Belly Bag